The Cell Imaging Facility provides training and consultation on the use of confocal microscopy, widefield automated microscopy, and software analysis tools for quantitative analysis of image data. The facility has locations across campus, each with confocal and widefield capabilities. There are several options for confocal microscopy of fixed or live samples, including Nikon A1R, Leica SP8 white light, Olympus FV1000s, Bruker Ultima 2 Photon and a Zeiss 880 Airyscan. We have a Nikon Ti automated microscopes with laser autofocus and stage incubators in addition to two Olympus widefield CCD systems. These instruments run using a variety of proprietary software platforms and some multifunctional image capture programs such as Metamorph, Micromanager, and Imaris software are available for 2D and 3D analysis of image data.
Web calendar for scheduling appointments: This system is core wide and uses the campus UNID system. Upon first login you will be asked for information and for which PI there is an authorized chartfield registered with the cores office. If you have problems logging in contact billing at billing@cores.utah.edu
Before working with us, please take the time to read our Microscopy Core Policies. To make a reservation to use our equipment or services, please go to resource.cores.utah.edu. Please arrange for a training appointment with core staff to become approved to use the instruments. Instruments are available 24/7 to appropriately trained users.
For questions, updates, and news check out our social media accounts!
Youtube Channel: @ U of U Microscopy or https://www.youtube.com/channel/UCTSL-YmOYtIfz34zzNRrF5A
Twitter Page: @UofUMicroscopy or https://twitter.com/UofUMicroscopy
Acknowledgments to the Cell Imaging Core
We would like to thank you for acknowledging the University of Utah Cell Imaging Core. This recognition allows us to highlight the impact of your work and demonstrates the important contributions the Cell Imaging Core makes to research across the University of Utah. The recognition our core receives from your acknowledgments also aids in receiving grants and further funding for equipment we can provide to our users.
Self-Users:
Please mention in your published papers the use of instruments via the University of Utah Cell Imaging Core and any notable staff member.
“We acknowledge Cell Imaging Core at the University of Utah for use of equipment (insert microscope(s) or instrument details here), and thank (insert any notable staff member – if desired) for their assistance.”
Assisted Imaging:
Please mention in your published papers the associate of our staff who took your images for you.
“We acknowledge Cell Imaging Core at the University of Utah for use of equipment (insert microscope(s) or instrument detail here), and thank (insert staff member-required) for their assistance in image acquisition.”
Collaboration:
Co-author acknowledgment, collaborations that assist with the methodologies and planning process of your experiment as well as instrument use. At this depth of assistance, this type of recognition is required.
A variety of instrumentation is available at the Cell Imaging Core. Click on links below for further information on these systems.
A variety of instrumentation is available at the HCI location. These include a Leica SP8 white light laser confocal and automated widefield. Click on links below for further information on these systems.
A variety of instrumentation is available at the CSC location at Room 032. Click on links below for further information on these systems
ASB – Aline Wilmot Skaggs Biology Building: map
Number: 82
Code: ASB
Address: 259 S 1400 E Salt Lake City, UT 84112
CSC – Crocker Science Center: map
Number: 5
Code: CSC
Address: 1390 Presidents Cir Salt Lake City, UT 84112
EEJMRB – E.E. Jones Medical Research: map
Number: 565
Code: EEJMRB
Address: 15 N Medical Dr East Salt Lake City, UT 84112
HCI – Huntsman Cancer Institute: map
Number: 555
Code: HCI
Address: 2000 Circle of Hope Salt Lake City, UT 84103
HSC – Health Science Center: map
Number: 585
Code: RB LAB
Address: 30 N 2030 E Salt Lake City, UT 84112
SMBB – Sorenson Molecular Biotechnology (USTAR): map
Number: 151
Code: SMBB
Address: 36 S Wasatch Dr Salt Lake City, UT 84112
To Set Up a User Account:
Account SetupBooking Calendar:
Booking Calendar- Fill out and submit a Work Authorization form. Work Authorization Form.
- If you need help navigating the form, a ‘How to’ guide is available under the drop down menu labeled ‘Work Auth Forms
- For additional questions please contact the administrative office at billing@cores.utah.edu
- All users must complete the online Laser Safety Training provided by EHS: https://utah.bridgeapp.com/learner/courses/2d8ad69f/enroll. Upon completion, email your certificate to support.cellimaging@cores.utah.edu
- We recommend an initial half hour project consultation with Xiang or Mike. This will help us ensure you obtain the best images possible from your samples. This can be arranged with the booking calendar. Instructions below.
- We require 1-2 hours of microscope training prior to solo use of the microscopes. Please schedule time with both the microscope you want to use and Xiang or Mike. This can be arranged with the booking calendar. Instructions below.
- We suggest that you book time with staff for the start of your first imaging session. We also suggest that you not book after hours imaging until you feel comfortable with the microscope.
- If you want assisted imaging instead of training, this should be booked like a training session, i.e., book both the microscope and staff.
- Booking on the calendar website
- Login using your unid (ex. uxxxxxx) and cis password.
- After logging in, the Cell Imaging Core calendar is located under ‘Resources’ and ‘Cell Imaging’
- Booking Consultation or Training
- Each Staff member and microscope has a calendar that shows availability that you may book time for your use. Note that our staff have normal consultation hours at HCI, CSC and HSC. For any questions regarding our calendar system please email us at support.cellimaging@cores.utah.edu.
- After booking staff member’s time, check the drop down option next to ‘Process’ to select the training location. In the ‘Description’ or ‘Service Needed’, please include information about your imaging needs (e.g., consultation, live cell imaging or SP8 Training).
- For training or assisted imaging, also book simultaneous time on the microscope.
- Booking a Microscope
- Book time with both the staff member and suggested microscope simultaneously for initial hardware and software training.
- Once trained, use the calendar to book time to use the microscope. Please note the cancelation policy below.
- Building access granted after full training is complete
- HCI
- Computer and building access forms will be provided
- Submit forms per our instructions
- HSC and CSC
- You must then go in person with your UID card to our Administrative Office to gain card access to the building and rooms to which you have been granted permissions. To get to our Administrative Office (Skaggs Bldg 582, Room 250), enter from the South doors, go up the stairs to the second floor, the offices are straight down the hall. (Map)
- SMBB
- We will send your information to the SMBB building office.
- HCI
If you have any more questions concerning this process please contact us at support.cellimaging@cores.utah.edu.
Calendar bookings must be deleted by the user 24 hours prior to the time reserved in order to avoid billing charges. Booking time cannot be altered or deleted and is non-refundable nor creditable if this time window is not met. The Cell Imaging Core is not liable if a user no longer needs their booking, if a user’s samples do not work, if a user cannot make their booking, etc. However, if an instrument is down, is offline, or is under maintenance all fees will be voided for that duration.
Users with overages or caught with unregistered time can be charged $100/h.
There are two tracks of training offered by the Cell Imaging Core
- Short time users: Patrons that plan on 20 hours or less of usage per year.
- Assisted Imaging
- Staff will image your samples exclusively with you. Your presence is required for an assessment consultation of your sample quality and image goals.
- Signature of a release form is required to insure the quality of samples and the resulting images.
- Acknowledgement in publications for the University of Utah Cell Imaging is a requirement for this type of extensive assistance.
- Assisted Imaging
- Long time users: Patrons that prefer in depth training for skill development with the goal of imaging yourself and to obtain rigorous understanding of software.
- Advanced training series
- Project consultation and basic training
- Advanced training for special software implementation (FRET, FRAP, live cell imaging, stitching, time lapse, ect.. )
- Advanced training series
Publications
Recent
- Almanzar, D. E., Gordon, S. G., Bristow, C., Hamrick, A., von Diezmann, L., Liu, H., & Rog, O. (2023). Meiotic DNA exchanges in C. elegans are promoted by proximity to the synaptonemal complex. Life Science Alliance, 6(4), e202301906. https://doi.org/10.26508/lsa.202301906
- Anderl, W. J., Pearson, N., Converse, M. I., Yu, S. M., & Monson, K. L. (2023). Strain-induced collagen denaturation is rate dependent in failure of cerebral arteries. Acta Biomaterialia. https://doi.org/10.1016/j.actbio.2023.04.032
- Ellis, K. E., Smihula, H., Ganguly, I., Vigato, E., Bervoets, S., Auer, T. O., Benton, R., Litwin-Kumar, A., & Caron, S. J. C. (2023). Evolution of connectivity architecture in the Drosophila mushroom body [Preprint]. Neuroscience. https://doi.org/10.1101/2023.02.10.528036
- Espino-Sanchez, T. J., Wienkers, H., Marvin, R. G., Nalder, S., García-Guerrero, A. E., VanNatta, P. E., Jami-Alahmadi, Y., Blackwell, A. M., Whitby, F. G., Wohlschlegel, J. A., Kieber-Emmons, M. T., Hill, C. P., & Sigala, P. A. (2023). Direct Tests of Cytochrome Function in the Electron Transport Chain of Malaria Parasites[Preprint]. Microbiology. https://doi.org/10.1101/2023.01.23.525242
- Ferrara, P. J., Reidy, P. T., Petrocelli, J. J., Yee, E. M., Fix, D. K., Mahmassani, Z. S., Montgomery, J. A., McKenzie, A. I., de Hart, N. M. M. P., & Drummond, M. J. (2023). Global deletion of CCL2 has adverse impacts on recovery of skeletal muscle fiber size and function and is muscle-specific. Journal of Applied Physiology. https://doi.org/10.1152/japplphysiol.00444.2022
- Hoffman, L. M., Jensen, C. C., & Beckerle, M. C. (2022). Phosphorylation of the small heat shock protein HspB1 regulates cytoskeletal recruitment and cell motility. Molecular Biology of the Cell, 33(11), ar100. https://doi.org/10.1091/mbc.E22-02-0057
- Petrocelli, J. J., Hart, N. M. M. P. de, Lang, M. J., Yee, E. M., Ferrara, P. J., Fix, D. K., Chaix, A., Funai, K., & Drummond, M. J. (2023). Cellular senescence and disrupted proteostasis induced by myotube atrophy are prevented with low-dose metformin and leucine cocktail. Aging, 15. https://doi.org/10.18632/aging.204600
- Preston, A. J., Rogers, A., Sharp, M., Mitchell, G., Toruno, C., Barney, B. B., Donovan, L. N., Bly, J., Kennington, R., Payne, E., Iovino, A., Furukawa, G., Robinson, R., Shamloo, B., Buccilli, M., Anders, R., Eckstein, S., Fedak, E. A., Wright, T., … Abegglen, L. M. (2023). Elephant TP53-RETROGENE 9 induces transcription-independent apoptosis at the mitochondria. Cell Death Discovery, 9(1), Article 1. https://doi.org/10.1038/s41420-023-01348-7
- Rice, M. C., Little, J. H., Forrister, D. L., Machado, J., Clark, N. L., & Gagnon, J. A. (2023). Gadusol is a maternally provided sunscreen that protects fish embryos from DNA damage [Preprint]. Developmental Biology. https://doi.org/10.1101/2023.01.30.526370
- Sefton, E. M., Gallardo, M., Tobin, C. E., Collins, B. C., Colasanto, M. P., Merrell, A. J., & Kardon, G. (2022). Fibroblast-derived Hgf controls recruitment and expansion of muscle during morphogenesis of the mammalian diaphragm. ELife, 11, e74592. https://doi.org/10.7554/eLife.74592
- Simeone, C. A., Wilkerson, J. L., Poss, A. M., Banks, J. A., Varre, J. V., Guevara, J. L., Hernandez, E. J., Gorsi, B., Atkinson, D. L., Turapov, T., Frodsham, S. G., Morales, J. C. F., O’Neil, K., Moore, B., Yandell, M., Summers, S. A., Krolewski, A. S., Holland, W. L., & Pezzolesi, M. G. (2022). A dominant negative ADIPOQ mutation in a diabetic family with renal disease, hypoadiponectinemia, and hyperceramidemia. Npj Genomic Medicine, 7(1), Article 1. https://doi.org/10.1038/s41525-022-00314-z
- Wang, Y., Chiola, S., Yang, G., Russell, C., Armstrong, C. J., Wu, Y., Spampanato, J., Tarboton, P., Ullah, H. M. A., Edgar, N. U., Chang, A. N., Harmin, D. A., Bocchi, V. D., Vezzoli, E., Besusso, D., Cui, J., Cattaneo, E., Kubanek, J., & Shcheglovitov, A. (2022). Modeling human telencephalic development and autism-associated SHANK3 deficiency using organoids generated from single neural rosettes. Nature Communications, 13(1), Article 1. https://doi.org/10.1038/s41467-022-33364-z
- Xue, Q., Varady, S. R. S., Waddell, T. Q. A., Roman, M. R., Carrington, J., & Roh-Johnson, M. (2023). Lack of Paxillin phosphorylation promotes single-cell migration in vivo. Journal of Cell Biology, 222(3), e202206078. https://doi.org/10.1083/jcb.202206078
- Zhang, C., Jin, Y., Marchetti, M., Lewis, M. R., Hammouda, O. T., & Edgar, B. A. (2022). EGFR signaling activates intestinal stem cells by promoting mitochondrial biogenesis and β-oxidation. Current Biology. https://doi.org/10.1016/j.cub.2022.07.003
2022
- Batot, G., Metcalf, C., Bell, L., Pauletti, A., Wilcox, K., & Bröer, S. (2022). A Model for Epilepsy of Infectious Etiology using Theiler’s Murine Encephalomyelitis Virus. Journal of Visualized Experiments. https://doi.org/10.3791/63673
- Cho, J. M., Park, S.-K., Kwon, O. S., La Salle, D. T., Cerbie, J., Fermoyle, C. C., Morgan, D., Nelson, A., Bledsoe, A., Bharath, L. P., Tandar, M., Kunapuli, S. P., Richardson, R. S., Anandh Babu, P. V., Mookherjee, S., Kishore, B. K., Wang, F., Yang, T., Boudina, S., … Symons, J. D. (2022). Activating P2Y1 receptors improves function in arteries with repressed autophagy. Cardiovascular Research, cvac061. https://doi.org/10.1093/cvr/cvac061
- Fadul, J., Zulueta-Coarasa, T., Slattum, G. M., Redd, N. M., Jin, M. F., Redd, M. J., Daetwyler, S., Hedeen, D., Huisken, J., & Rosenblatt, J. (2021). KRas-transformed epithelia cells invade and partially dedifferentiate by basal cell extrusion. Nature Communications, 12(1), 7180. https://doi.org/10.1038/s41467-021-27513-z
- Falekun, S., Sepulveda, J., Jami-Alahmadi, Y., Park, H., Wohlschlegel, J. A., & Sigala, P. A. (2021). Divergent acyl carrier protein decouples mitochondrial Fe-S cluster biogenesis from fatty acid synthesis in malaria parasites. ELife, 10, e71636. https://doi.org/10.7554/eLife.71636
- Ferrara, P. J., Verkerke, A. R. P., Maschek, J. A., Shahtout, J. L., Siripoksup, P., Eshima, H., Johnson, J. M., Petrocelli, J. J., Mahmassani, Z. S., Green, T. D., McClung, J. M., Cox, J. E., Drummond, M. J., & Funai, K. (2021). Low lysophosphatidylcholine induces skeletal muscle myopathy that is aggravated by high‐fat diet feeding. The FASEB Journal, 35(10). https://doi.org/10.1096/fj.202101104R
- Figueroa, K., Anderson, C. J., Paul, S., Dansithong, W., Gandelman, M., Scoles, D. R., & Pulst, S. M. (2022). Slc9a6 mutation causes Purkinje cell loss and ataxia in the shaker rat [Preprint]. Neuroscience. https://doi.org/10.1101/2022.03.28.486143
- Fix, D. K., Ekiz, H. A., Petrocelli, J. J., Mckenzie, A. M., Mahmassani, Z. S., O’Connell, R. M., & Drummond, M. J. (2021). Disrupted macrophage metabolic reprogramming in aged soleus muscle during early recovery following disuse atrophy. Aging Cell, 20(9). https://doi.org/10.1111/acel.13448
- Fix, D. K., Mahmassani, Z. S., Petrocelli, J. J., de Hart, N. M. M. P., Ferrara, P. J., Painter, J. S., Nistor, G., Lane, T. E., Keirstead, H. S., & Drummond, M. J. (2021). Reversal of deficits in aged skeletal muscle during disuse and recovery in response to treatment with a secrotome product derived from partially differentiated human pluripotent stem cells. GeroScience, 43(6), 2635–2652. https://doi.org/10.1007/s11357-021-00423-0
- Guillen, K. P., Fujita, M., Butterfield, A. J., Scherer, S. D., Bailey, M. H., Chu, Z., DeRose, Y. S., Zhao, L., Cortes-Sanchez, E., Yang, C.-H., Toner, J., Wang, G., Qiao, Y., Huang, X., Greenland, J. A., Vahrenkamp, J. M., Lum, D. H., Factor, R. E., Nelson, E. W., … Welm, A. L. (2022). A human breast cancer-derived xenograft and organoid platform for drug discovery and precision oncology. Nature Cancer, 3(2), 232–250. https://doi.org/10.1038/s43018-022-00337-6
- Happ, J. T., Arveseth, C. D., Bruystens, J., Bertinetti, D., Nelson, I. B., Olivieri, C., Hedeen, D. S., Zhu, J.-F., Capener, J. L., Bröckel, J. W., Vu, L., King, C. C., Ruiz-Perez, V. L., Veglia, G., Herberg, F. W., Taylor, S. S., & Myers, B. R. (2021). A PKA Inhibitor Motif within Smoothened Controls Hedgehog Signal Transduction. bioRxiv. https://doi.org/10.1101/2021.07.05.451193
- Hill, J. H., Massaquoi, M. S., Sweeney, E. G., Wall, E. S., Jahl, P., Bell, R., Kallio, K., Derrick, D., Murtaugh, L. C., Parthasarathy, R., Remington, S. J., Round, J. L., & Guillemin, K. (2022). A microbiota membrane disrupter disseminates to the pancreas and increases β-cell mass (p. 2022.03.24.485696). bioRxiv. https://doi.org/10.1101/2022.03.24.485696
- Ingram, K., Samson, S. C., Zewdu, R., Zitnay, R. G., Snyder, E. L., & Mendoza, M. C. (2022). NKX2-1 controls lung cancer progression by inducing DUSP6 to dampen ERK activity. Oncogene, 41(2), 293–300. https://doi.org/10.1038/s41388-021-02076-x
- Jensen, O., Trivedi, S., Meier, J. D., Fairfax, K. C., Hale, J. S., & Leung, D. T. (2022). A subset of follicular helper-like MAIT cells can provide B cell help and support antibody production in the mucosa. Science Immunology, 7(67), eabe8931. https://doi.org/10.1126/sciimmunol.abe8931
- Kaur, K., Mohammadpour, R., Ghandehari, H., Reilly, C. A., Paine, R., & Kelly, K. E. (2022). Effect of combustion particle morphology on biological responses in a Co-culture of human lung and macrophage cells. Atmospheric Environment, 284, 119194. https://doi.org/10.1016/j.atmosenv.2022.119194
- Kaur, K., Mohammadpour, R., Sturrock, A., Ghandehari, H., Reilly, C., Paine, R., & Kelly, K. E. (2022). Comparison of biological responses between submerged, pseudo-air-liquid interface, and air-liquid interface exposure of A549 and differentiated THP-1 co-cultures to combustion-derived particles. Journal of Environmental Science and Health, Part A, 1–12. https://doi.org/10.1080/10934529.2022.2083429
- Kidwell, C. U., Casalini, J. R., Pradeep, S., Scherer, S. D., Greiner, D., Johnson, J. S., Olson, G. S., Rutter, J., Welm, A. L., Zangle, T. A., & Roh-Johnson, M. (2021). Laterally transferred macrophage mitochondria act as a signaling source promoting cancer cell proliferation. bioRxiv. https://doi.org/10.1101/2021.08.10.455713
- Kursel, L. E., Cope, H. D., & Rog, O. (2021). Unconventional conservation reveals structure-function relationships in the synaptonemal complex. ELife, 10, e72061. https://doi.org/10.7554/eLife.72061
- LaBelle, S. A., Dinkins, S. S., Hoying, J. B., Budko, E. V., Rauff, A., Strobel, H. A., Lin, A. H., & Weiss, J. A. (2022). Matrix anisotropy promotes angiogenesis in a density-dependent manner. American Journal of Physiology-Heart and Circulatory Physiology, 322(5), H806–H818. https://doi.org/10.1152/ajpheart.00072.2022
- Lai, S.-C. A., Gundlapalli, H., Ekiz, H. A., Jiang, A., Fernandez, E., & Welm, A. L. (2021). Blocking Short-Form Ron Eliminates Breast Cancer Metastases through Accumulation of Stem-Like CD4+ T Cells That Subvert Immunosuppression. Cancer Discovery, 11(12), 3178–3197. https://doi.org/10.1158/2159-8290.CD-20-1172
- Lam, G., Beebe, K., & Thummel, C. S. (2022). A direct-drive GFP reporter for studies of tracheal development in Drosophila. Fly, 16(1), 105–110. https://doi.org/10.1080/19336934.2022.2030191
- Lin, Y., Perovanovic, J., Kong, Y., Igyarto, B. Z., Zurawski, S., Tantin, D., Zurawski, G., Bettini, M., & Bettini, M. L. (2022). Antibody-Mediated Targeting of a Hybrid-Insulin-Peptide Towards Neonatal Thymic Langerin+ Cells Enhances T Cell Central Tolerance and Delays Autoimmune Diabetes. Diabetes, db211069. https://doi.org/10.2337/db21-1069
- Liu, H., Gordon, S. G., & Rog, O. (2021). Heterologous synapsis in C. elegans is regulated by meiotic double-strand breaks and crossovers. Chromosoma, 130(4), 237–250. https://doi.org/10.1007/s00412-021-00763-y
- Marchetti, M., Zhang, C., & Edgar, B. A. (2021). An improved organ explant culture method reveals stem cell lineage dynamics in the adult Drosophila intestine. bioRxiv. https://doi.org/10.1101/2021.12.17.473114
- Mathew, B., Aoyagi, K. L., & Fisher, M. A. (2021). Yersinia pestis Lipopolysaccharide Remodeling Confers Resistance to a Xenopsylla cheopis Cecropin. ACS Infectious Diseases, 7(8), 2536–2545. https://doi.org/10.1021/acsinfecdis.1c00275
- McKenzie, A. I., Mahmassani, Z. S., Petrocelli, J. J., de Hart, N. M. M. P., Fix, D. K., Ferrara, P. J., LaStayo, P. C., Marcus, R. L., Rondina, M. T., Summers, S. A., Johnson, J. M., Trinity, J. D., Funai, K., & Drummond, M. J. (2022). Short-term exposure to a clinical dose of metformin increases skeletal muscle mitochondrial H2O2 emission and production in healthy, older adults: A randomized controlled trial. Experimental Gerontology, 163, 111804. https://doi.org/10.1016/j.exger.2022.111804
- Meng, F., Fleming, B. A., Jia, X., Rousek, A. A., Mulvey, M. A., & Ward, D. M. (2022). Lysosomal iron recycling in mouse macrophages is dependent upon both LcytB and Steap3 reductases. Blood Advances, 6(6), 1692–1707. https://doi.org/10.1182/bloodadvances.2021005609
- Nicholson, R. J., Poss, A. M., Maschek, J. A., Cox, J. E., Hopkins, P. N., Hunt, S. C., Playdon, M. C., Holland, W. L., & Summers, S. A. (2021). Characterizing a Common CERS2 Polymorphism in a Mouse Model of Metabolic Disease and in Subjects from the Utah CAD Study. The Journal of Clinical Endocrinology & Metabolism, 106(8), e3098–e3109. https://doi.org/10.1210/clinem/dgab155
- Nie, X., Munyoki, S. K., Sukhwani, M., Schmid, N., Missel, A., Emery, B. R., DonorConnect, Stukenborg, J.-B., Mayerhofer, A., Orwig, K. E., Aston, K. I., Hotaling, J. M., Cairns, B. R., & Guo, J. (2022). Single-cell analysis of human testis aging and correlation with elevated body mass index. Developmental Cell, 57(9), 1160-1176.e5. https://doi.org/10.1016/j.devcel.2022.04.004
- Okada, M., Rajaram, K., Swift, R. P., Mixon, A., Maschek, J. A., Prigge, S. T., & Sigala, P. A. (2022). Critical role for isoprenoids in apicoplast biogenesis by malaria parasites. ELife, 11, e73208. https://doi.org/10.7554/eLife.73208
- Ost, K. S., O’Meara, T. R., Stephens, W. Z., Chiaro, T., Zhou, H., Penman, J., Bell, R., Catanzaro, J. R., Song, D., Singh, S., Call, D. H., Hwang-Wong, E., Hanson, K. E., Valentine, J. F., Christensen, K. A., O’Connell, R. M., Cormack, B., Ibrahim, A. S., Palm, N. W., … Round, J. L. (2021). Adaptive immunity induces mutualism between commensal eukaryotes. Nature, 596(7870), 114–118. https://doi.org/10.1038/s41586-021-03722-w
- Øvrebø, J. I., Bradley-Gill, M.-R., Zielke, N., Kim, M., Marchetti, M., Bohlen, J., Lewis, M., van Straaten, M., Moon, N.-S., & Edgar, B. A. (2022). Translational control of E2f1 regulates the Drosophila cell cycle. Proceedings of the National Academy of Sciences, 119(4), e2113704119. https://doi.org/10.1073/pnas.2113704119
- Petrocelli, J. J., Mahmassani, Z. S., Fix, D. K., Montgomery, J. A., Reidy, P. T., McKenzie, A. I., de Hart, N. M., Ferrara, P. J., Kelley, J. J., Eshima, H., Funai, K., & Drummond, M. J. (2021). Metformin and leucine increase satellite cells and collagen remodeling during disuse and recovery in aged muscle. The FASEB Journal, 35(9). https://doi.org/10.1096/fj.202100883R
- Rheinemann, L., Downhour, D. M., Bredbenner, K., Mercenne, G., Davenport, K. A., Schmitt, P. T., Necessary, C. R., McCullough, J., Schmitt, A. P., Simon, S. M., Sundquist, W. I., & Elde, N. C. (2021). RetroCHMP3 blocks budding of enveloped viruses without blocking cytokinesis. Cell, 184(21), 5419-5431.e16. https://doi.org/10.1016/j.cell.2021.09.008
- Tamamouna, V., Rahman, M. M., Petersson, M., Charalambous, I., Kux, K., Mainor, H., Bolender, V., Isbilir, B., Edgar, B. A., & Pitsouli, C. (2021). Remodelling of oxygen-transporting tracheoles drives intestinal regeneration and tumorigenesis in Drosophila. Nature Cell Biology, 23(5), 497–510. https://doi.org/10.1038/s41556-021-00674-1
- Van Deren, D. A., De, S., Xu, B., Eschenbacher, K. M., Zhang, S., & Capecchi, M. R. (2022). Defining the Hoxb8 cell lineage during murine definitive hematopoiesis. Development, 149(8), dev200200. https://doi.org/10.1242/dev.200200
- Wenzel, D. M., Mackay, D. R., Skalicky, J. J., Paine, E. L., Miller, M. S., Ullman, K. S., & Sundquist, W. I. (2022). Comprehensive analysis of the human ESCRT-III-MIT domain interactome reveals new cofactors for cytokinetic abscission. bioRxiv. https://doi.org/10.1101/2022.02.09.477148
- Wojtalewicz, S., Vizmeg, J., Erickson, S., Lade, C., Shea, J., Sant, H., Magda, J., Gale, B., Agarwal, J., & Davis, B. (2022). Evaluating the influence of particle morphology and density on the viscosity and injectability of a novel long-acting local anesthetic suspension. Journal of Biomaterials Applications, 8853282221106486. https://doi.org/10.1177/08853282221106486
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- Yang, G., Parker, E., Gorsi, B., Liebowitz, M., Maguire, C., King, J. B., Coon, H., Lopez-Larson, M., Anderson, J., Yandell, M., & Shcheglovitov, A. (2022). Neurite outgrowth deficits caused by rare PLXNB1 mutation in pediatric bipolar disorder [Preprint]. Psychiatry and Clinical Psychology. https://doi.org/10.1101/2022.05.06.22274499
- Zhang, P., Katzaroff, A. J., Buttitta, L. A., Ma, Y., Jiang, H., Nickerson, D. W., Øvrebø, J. I., & Edgar, B. A. (2021). The Krüppel-like factor Cabut has cell cycle regulatory properties similar to E2F1. Proceedings of the National Academy of Sciences of the United States of America, 118(7), e2015675118. https://doi.org/10.1073/pnas.2015675118
- Zhao, H., Pomicter, A. D., Eiring, A. M., Franzini, A., Ahmann, J., Hwang, J.-Y., Senina, A., Helton, B., Iyer, S., Yan, D., Khorashad, J. S., Zabriskie, M. S., Agarwal, A., Redwine, H. M., Bowler, A. D., Clair, P. M., McWeeney, S. K., Druker, B. J., Tyner, J. W., … Deininger, M. W. (2022). MS4A3 promotes differentiation in chronic myeloid leukemia by enhancing common β-chain cytokine receptor endocytosis. Blood, 139(5), 761–778. https://doi.org/10.1182/blood.2021011802
2021
- Ahmed, S., Maldera, J., Krunic, D., Paiva-Silva, G., Penalva, C., Teleman, A., & Edgar, B. (2020). Fitness trade-offs incurred by ovary-to-gut steroid signalling in Drosophila. Nature, 584(7821), 415-+. doi:10.1038/s41586-020-2462-y
- Auer, T. O., Khallaf, M. A., Silbering, A. F., Zappia, G., Ellis, K., Álvarez-Ocaña, R., Arguello, J. R., Hansson, B. S., Jefferis, G. S. X.E, Caron, S. J. C., Knaden, M., & Benton, R. (2020). Olfactory receptor and circuit evolution promote host specialization. Nature, 579(7799), 402-408. doi:10.1038/s41586-020-2073-7
- Bell, L. A., Wallis, G. J., & Wilcox, K. S. (2020). Reactivity and increased proliferation of NG2 cells following central nervous system infection with Theiler’s murine encephalomyelitis virus. J Neuroinflammation, 17(1), 369. doi:10.1186/s12974-020-02043-5
- Bhatlekar, S., Manne, B. K., Basak, I., Edelstein, L. C., Tugolukova, E., Stoller, M. L., Cody, M. J., Morley, S. C., Nagalla, S., Weyrich, A. S., Rowley, J. W., O’Connell, R. M.,Rondina, M. T., Campbell, R. A., & Bray, P. F. (2020). miR-125a-5p regulates megakaryocyte proplatelet formation via the actin-bundling protein L-plastin. Blood, 136(15), 1760-1772. doi:10.1182/blood.2020005230
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- Dong, Z. M., Lin, E., Wechsler, M. E., Weller, P. F., Klion, A. D., Bochner, B. S., Delker, D. A., Hazel, M. W., Fairfax, K., Khoury, P., Akuthota, P., Merkel, P. A., Dyer, A. M., Langford, C., Specks, U., Gleich, G. J., Chinchilli, V. M., Raby, B., Yandell, M., & Clayton, F. (2020). Pulmonary Eosinophilic Granulomatosis with Polyangiitis Has IgG4 Plasma Cells and Immunoregulatory Features. Am J Pathol, 190(7), 1438-1448. doi:10.1016/j.ajpath.2020.03.005
- Eshima, H., Siripoksup, P., Mahmassani, Z., Johnson, J., Ferrara, P., Verkerke, A., Salcedo, A., Drummond, M.J., & Funai, K. (2020). Neutralizing mitochondrial ROS does not rescue muscle atrophy induced by hindlimb unloading in female mice. Journal of Applied Physiology, 129(1), 124-132. doi:10.1152/japplphysiol.00456.2019
- Ferrara, P. J., Rong, X., Maschek, J. A., Verkerke, A. R., Siripoksup, P., Song, H., Green, T. D., Krishnan, K. C., Johnson, J. M., Turk, J., Houmard, J. A., Lusis, A. J., Drummond, M. J., McClung, J. M., Cox, J. E., Shaikh, S. R., Tontonoz, P., Holland, W. L., & Funai, K. (2021). Lysophospholipid acylation modulates plasma membrane lipid organization and insulin sensitivity in skeletal muscle. J Clin Invest, 131(8). doi:10.1172/JCI135963
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- Keefe, M. D., Soderholm, H. E., Shih, H. Y., Stevenson, T. J., Glaittli, K. A., Bowles, D. M., Scholl, E., Colby, S., Merchant, S., Hsu, E. W., & Bonkowsky, J. L. (2020). Vanishing white matter disease expression of truncated EIF2B5 activates induced stress response. Elife, 9. doi:10.7554/eLife.56319
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- Lyu, Y., Verma, V. K., Lee, Y., Taleb, I., Badolia, R., Shankar, T. S., Kyriakopoulos, C. P., Selzman, C. H., Caine, W., Alharethi, R., Navankasattusas, S., Seidel, T., Drakos, S. G., & Sachse, F. B. (2021). Remodeling of t-system and proteins underlying excitation-contraction coupling in aging versus failing human heart. NPJ Aging Mech Dis, 7(1), 16. doi:10.1038/s41514-021-00066-7
- Mahmassani, Z. S., McKenzie, A. I., Petrocelli, J. J., de Hart, N. M., Reidy, P. T., Fix, D. K., Ferrara, P. J., Funai, K., & Drummond, M. J. (2021). Short-term metformin ingestion by healthy older adults improves myoblast function. Am J Physiol Cell Physiol, 320(4), C566-C576. doi:10.1152/ajpcell.00469.2020
- Mathew, B., Aoyagi, K. L., & Fisher, M. A. (2021). Yersinia pestis lipopolysaccharide remodeling confers resistance to a Xenopsylla cheopis cecropin. bioRxiv, 2021.2003.2012.435208. doi:10.1101/2021.03.12.435208
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- Tamamouna, V, Rahman, MM, Petersson, M, Charalambous, I, Kux, K, Mainor, H, Bolender, V, Isbilir, B, Edgar, BA, & Pitsouli, C. (2021). Remodelling of oxygen-transporting tracheoles drives intestinal regeneration and tumorigenesis in Drosophila. Nature Cell Biology, 23(5), 497-+. doi:10.1038/s41556-021-00674-1
- Wike, C. L., Guo, Y., Tan, M., Nakamura, R., Shaw, D. K., Díaz, N., Whittaker-Tademy, A. F., Durand, N. C., Aiden, E. L., Vaquerizas, J. M., Grunwald, D., Takeda, H., & Cairns, B. R. (2021). Chromatin architecture transitions from zebrafish sperm through early embryogenesis. Genome Res, 31(6), 981-994. doi:10.1101/gr.269860.120
- Zhang, P., Katzaroff, A. J., Buttitta, L. A., Ma, Y., Jiang, H., Nickerson, D. W., Øvrebø, J. I., & Edgar, B. A. (2021). The Krüppel-like factor Cabut has cell cycle regulatory properties similar to E2F1. Proc Natl Acad Sci U S A, 118(7). doi:10.1073/pnas.2015675118
2020
- Deshpande, I., Liang, J., Hedeen, D., Roberts, K. J., Zhang, Y., Ha, B., Manglik, A. (2019). Smoothened stimulation by membrane sterols drives Hedgehog pathway activity. Nature, 571(7764), 284-288. doi:10.1038/s41586-019-1355-4
- Dong, Z. M., Lin, E., Wechsler, M. E., Weller, P. F., Klion, A. D., Bochner, B. S., Clayton, F. (2020). Pulmonary Eosinophilic Granulomatosis with Polyangiitis Has IgG4 Plasma Cells and Immunoregulatory Features. Am J Pathol, 190(7), 1438-1448. doi:10.1016/j.ajpath.2020.03.005
- Feng, H., Hockin, M., Zhang, S., Capecchi, M., Gale, B., & Sant, H. (2020). Enhanced chromosome extraction from cells using a pinched flow microfluidic device. Biomed Microdevices, 22(2), 25. doi:10.1007/s10544-020-0477-7
- Feng, H., Magda, J. J., & Gale, B. K. (2019). Viscoelastic second normal stress difference dominated multiplestream particle focusing in microfluidic channels. Appl Phys Lett, 115(26), 263702. doi:10.1063/1.5129281
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- Hanak, T. J., Libbey, J. E., Doty, D. J., Sim, J. T., DePaula-Silva, A. B., & Fujinami, R. S. (2019). Positive modulation of mGluR5 attenuates seizures and reduces TNF-alpha(+) macrophages and microglia in the brain in a murine model of virus-induced temporal lobe epilepsy. Exp Neurol, 311, 194-204.
doi:10.1016/j.expneurol.2018.10.006 - Hoffman, L. M., Smith, M. A., Jensen, C. C., Yoshigi, M., Blankman, E., Ullman, K. S., & Beckerle, M. C. (2020). Mechanical stress triggers nuclear remodeling and the formation of transmembrane actin nuclear lines with associated nuclear pore complexes. Mol Biol Cell, 31(16), 1774-1787. doi:10.1091/mbc.E19-01-0027
- Kim, H. S., Neugebauer, J., McKnite, A., Tilak, A., & Christian, J. L. (2019). BMP7 functions predominantly as a heterodimer with BMP2 or BMP4 during mammalian embryogenesis. Elife, 8. doi:10.7554/eLife.48872
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- Mahmassani, Z. S., Reidy, P. T., McKenzie, A. I., Petrocelli, J. J., Matthews, O., de Hart, N. M., Drummond, M. J. (2020). Absence of MyD88 from Skeletal Muscle Protects Female Mice from Inactivity-Induced Adiposity and Insulin Resistance. Obesity (Silver Spring), 28(4), 772-782. doi:10.1002/oby.22759
- McKenzie, A. I., Reidy, P. T., Nelson, D. S., Mulvey, J. L., Yonemura, N. M., Petrocelli, J. J., Drummond, M. J. (2020). Pharmacological inhibition of TLR4 ameliorates muscle and liver ceramide content after disuse in previously physically active mice. Am J Physiol Regul Integr Comp Physiol, 318(3), R503-R511. doi:10.1152/ajpregu.00330.2019
- Reidy, P. T., Yonemura, N. M., Madsen, J. H., McKenzie, A. I., Mahmassani, Z. S., Rondina, M. T., Drummond, M. J. (2019). An accumulation of muscle macrophages is accompanied by altered insulin sensitivity after reduced activity and recovery. Acta Physiol (Oxf), 226(2), e13251. doi:10.1111/apha.13251
2019
- Reidy, P. T., McKenzie, A. I., Mahmassani, Z. S., Petrocelli, J. J., Nelson, D. B., Lindsay, C. C., Drummond, M. J. (2019). Aging impairs mouse skeletal muscle macrophage polarization and muscle-specific abundance during recovery from disuse. Am J Physiol Endocrinol Metab, 317(1), E85-E98. doi:10.1152/ajpendo.00422.2018
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2018
- Abdul-Wajid, S., Demarest, B. L., & Yost, H. J. (2018). Loss of embryonic neural crest derived cardiomyocytes causes adult onset hypertrophic cardiomyopathy in zebrafish. Nat Commun, 9(1), 4603. doi:10.1038/s41467-018-07054-8
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- Mimche, P. N., Lee, C. M., Mimche, S. M., Thapa, M., Grakoui, A., Henkemeyer, M., & Lamb, T. J. (2018). EphB2 receptor tyrosine kinase promotes hepatic fibrogenesis in mice via activation of hepatic stellate cells. Sci Rep, 8(1), 2532. doi:10.1038/s41598-018-20926-9
- Reidy, P. T., McKenzie, A. I., Mahmassani, Z., Morrow, V. R., Yonemura, N. M., Hopkins, P. N., Drummond, M. J. (2018). Skeletal muscle ceramides and relationship with insulin sensitivity after 2 weeks of simulated sedentary behaviour and recovery in healthy older adults. J Physiol, 596(21), 5217-5236. doi:10.1113/JP276798
- Sefton, E. M., Gallardo, M., & Kardon, G. (2018). Developmental origin and morphogenesis of the diaphragm, an essential mammalian muscle. Dev Biol, 440(2), 64-73. doi:10.1016/j.ydbio.2018.04.010
- Zitnay, J. L., Reese, S. P., Tran, G., Farhang, N., Bowles, R. D., & Weiss, J. A. (2018). Fabrication of dense anisotropic collagen scaffolds using biaxial compression. Acta Biomater, 65, 76-87. doi:10.1016/j.actbio.2017.11.017
- Zitnay, J. L., & Weiss, J. A. (2018). Load transfer, damage, and failure in ligaments and tendons. J Orthop Res, 36(12), 3093-3104. doi:10.1002/jor.24134
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Xiang Wang Ph.D., Director
xiang.wang@cores.utah.edu

HSC – Health Science Center (585)
Office Phone Number: 801-587-7964
Office Room Numbers:
Room 55 – Michael Bridge
Room 48a – Xiang Wang
Room 48e – Bill James
HCI – Huntsman Cancer Institute (555)
Office Phone Number: 801-585-0106
Office Room Number: 1460
CSC – Crocker Science Center (5)
Office Phone Number: 801-587-0313
Office Room Number: 30
Chair:
Bruce Edgar, Professor, Oncological Sciences
Committee:
James Cox, HSC Cores Director
Alex Shcheglovitov, Assistant Professor, Neurobiology and Anatomy
Mark Smith, Research Assistant Professor, Oncological Sciences
Markus Babst, Professor, Biological Sciences
Michelle Mendoza, Associate Professor, Oncological Sciences
Minna Roh-Johnson, Assistant Professor, Dept. of Biochemistry
Sophie Caron, Assistant Professor, Biological Sciences
Gabrielle Kardon, Professor, Human Genetics