Metabolomics Core Facility
The University of Utah Metabolomics Core uses mass spectrometry as a platform to provide high-quality metabolomics data for the University of Utah researchers, academic collaborators, and commercial applications. The core specializes in LC-MS and GC-MS metabolomics and lipidomics analysis, as well as metabolite quantitation. The core was initiated by a NIDDK funded Center of Excellence in Molecular Hematology and continues to be funded by an NIDDK Cooperative Centers of Excellence in Hematology award. The laboratory is fit with a number of state-of-the-art instruments and staffed by three Ph.D. level scientists and two BS level specialists, with over 40 combined years of mass spectrometry experience.
Due to the chemical diversity of the metabolome, no single platform or extraction method exists. Therefore, the core offers multiple complimentary services: GC-MS targeted and non-targeted metabolomics, LC-MS targeted and non-targeted metabolomics, and metabolite quantification. Non-targeted metabolomics is a preferred way for the discovery of metabolic biomarkers and generating initial hypothesis. Targeted metabolomics is employed to target specific metabolic pathways for hypothesis driven research. Additionally, targeted metabolomics is also employed when more sensitivity is required, or absolute quantitation is needed. Please contact the core before beginning a project for help determining which type of analysis is correct for your research.
The lipidomics division within the University of Utah’s Metabolomics Core is well-equipped with state-of-the-art instrumentation and a team of experts. We provide lipidome profiling services for a wide range of biological samples, including serum, urine, tissues, Drosophila, C. elegans, yeast, and bacteria. Our approach encompasses both targeted and non-targeted analysis methods, utilizing an Agilent 6545A UPLC-QToF-MS for discovery lipidomics, Agilent 6490 QQQ UPLC-MS, and SCIEX 6500 QTRAP QQQ UPLC-MS for precise metabolite quantification. The core facility also offers tailored assays for acyl carnitines and sphingolipids, as well as the capability to create custom, targeted platforms to cater to the unique needs of our researchers and collaborators.
To develop an effective metabolite and lipid profiling strategy please consult with Core staff prior to sample submission. This will determine project feasibility and in some cases a pilot project will be needed. This consultation is necessary to determine which extraction and instrumentation would be optimal for your project. A preliminary quote can/will be generated based upon this consultation.
Hours of Operation
9:00 am to 5:00 pm
Monday – Friday
