Cores Management Systems
Core Facilities
Affiliated Sites / University Resources

Drug Discovery Core

The Drug Discovery Core at the University of Utah is an established Service/Recharge center that provides compound collections for screening by University of Utah Faculty. Our mission is to provide customers low-cost and efficient access to chemical libraries for screening, to equipment for automation, and to synthetic chemistry support for the characterization and validation of compounds for potential use as therapeutics, diagnostics and biological tools.

  • Services
  • High-throughput screening
  • Small molecule chemical libraries
  • Pooled CRISPR-Cas9 libraries/Screening
  • Assay development
  • Consultation on target identification/validation, hit to lead optimization, PK/PD/Efficacy
  • Chemical support for drug discovery

CRISPR Knockout/Knockin Cell Line Production – In collaboration with the Mutation Generation and Detection Core, we started to offer a full cell line generation service from sgRNA design/construction to final cell line generation/verification. 

  • Viral Packaging Service
  • Small/large scale viral (lentivirus, adeno-associated virus) packaging, titrations, concentrations and transductions of cells of interest.
  • Lentivirus delivery of Cas9 and sgRNA

Hours of Operation

9:00 am to 5:00 pm
Monday – Friday

Service Rates

— This facility has not provided training documentation. —

Bai Liu
Drug Discovery Core Director

Contact Me
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Recent Mentions

  1. Hicks, K. G., A. A. Cluntun, H. L. Schubert, S. R. Hackett, J. A. Berg, P. G. Leonard, M. A. Ajalla Aleixo, Y. Zhou, A. J. Bott, S. R. Salvatore, F. Chang, A. Blevins, P. Barta, S. Tilley, A. Leifer, A. Guzman, A. Arok, S. Fogarty, J. M. Winter, H. C. Ahn, K. N. Allen, S. Block, I. A. Cardoso, J. Ding, I. Dreveny, W. C. Gasper, Q. Ho, A. Matsuura, M. J. Palladino, S. Prajapati, P. Sun, K. Tittmann, D. R. Tolan, J. Unterlass, A. P.VanDemark, M. G. Vander Heiden, B. A. Webb, C. H. Yun, P. Zhao, B. Wang, F. J. Schopfer, C. P. Hill, M. C. Nonato, F. L. Muller, J. E. Cox and J. Rutter (2023). Protein-metabolite interactomics of carbohydrate metabolism reveal regulation of lactate dehydrogenase. Science 379(6636): 996-1003.10.1126/science.abm3452
  2. McCullough, B. S., H. Wang and A. M. Barrios (2022). Inhibitor Screen Identifies Covalent Inhibitors of the Protein Histidine Phosphatase PHPT1. ACS Med Chem Lett 13(7): 1198- 1201.10.1021/acsmedchemlett.2c00053

Citing Our Facility

Acknowledgments

We would like to thank you for acknowledging the our facility. This recognition allows us to highlight the impact of your work and demonstrates the important contributions of our facility makes to research across the University of Utah. The recognition our core receives from your acknowledgments also aids in receiving grants and further funding for equipment and services we can provide to our users.

Self-Run Services / Instrumentation Usage:

In published papers that used instruments at our facility and notably involved staff members please use the following format:

“We acknowledge (facility name) at the University of Utah for use of equipment (insert instrument/service details here), and thank (insert any notable staff member – if desired) for their assistance.”

Assisted Services:

In published papers where a staff member assisted you in addition to the requested services please use the following format:

“We acknowledge (facility name) at the University of Utah for use of equipment (insert instrument/service details here), and thank (insert staff member-required) for their assistance in (service provided).”

Collaboration:

For publications resulting from collaborations that assisted with the methodologies, planning process and execution of your experiment in addition to equipment usage we require Co-author attribution on your publication for our facility and any staff members who provided substantial contributions to the originating project.